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Preclinical Studies Show That the Ketogenic Diet May Enhance the Treatment of Pancreatic Cancer

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Preclinical studies by Ludwig Cancer Research have shown that a common weight-loss diet may increase the effectiveness of chemotherapy for pancreatic cancer.Published in the journal MedThis study found that a ketogenic diet, or high fat, moderate protein, and very low carbohydrate intake, synergized with chemotherapy, with chemotherapy alone in a rigorous mouse model of pancreatic ductal adenocarcinoma (PDAC). It shows that the survival time is tripled in comparison.

Researchers led by Joshua Rabinowitz, director of the Ludwig Princeton branch, explain the findings and explain the therapeutic benefits of a complex study of how the ketogenic diet affects the metabolism of PDAC tumors. Identify the mechanism. Their findings are currently being evaluated in a clinical trial (NCT04631445). Ketogenic diet PDAC patients receiving chemotherapy.

“There was real progress against Pancreatic cancer “In the last two decades, the problem is that when many patients stabilize or shrink their tumors, the benefits of chemotherapy are very high,” said Rabino Witz, a professor at Princeton University’s Faculty of Chemotherapy and the Lewis Sigler Institute for Integrated Genome. Short-lived. Patients often extend their lifespan from 6 months to 1 year, but rarely see an extension of survival of at least 3 years, which people want. “

Substantial preclinical evidence suggests that fasting, or a diet with a metabolic effect similar to fasting, may enhance treatment for a variety of cancers. The ketogenic diet mimics fasting by reducing circulating glucose and lowering the levels of insulin, the hormone that causes tissues and tumors to consume sugar.Insulin cancer Glucose is a very important fuel for the growth of cancer cells, but it grows especially in pancreatic tumors. Rabinowitz’s own study previously revealed that PDAC tumors, despite their aggressive growth, are deficient in glucose. This suggested that they could be particularly vulnerable to additional glucose deficiency.

In the current study, Rabinowitz and his colleagues used mice designed to develop PDAC, or mice transplanted with tumors similar to those found in patients, early from Stand Up to Cancer. With continuous support, we have conducted multiple experiments over the years. Mice were fed either a normal carbohydrate-rich diet or a ketogenic diet and treated with the standard combination of chemotherapy, nab-paclitaxel (Abraxane), gemcitabine, and cisplatin.

They found that the ketogenic diet alone did not affect tumor growth. However, when combined with chemotherapy, the median survival time was tripled. In particular, the therapeutic effect was independent of the immune system, but only mice with an intact immune system were among the long-term survivors.

Rabinowitz and his team also conducted a study to investigate the effects of combination therapies on tumor metabolism. “We know that glucose is the main cancer fuel, insulin is the hormone that promotes cancer, and a ketogenic diet in a single stroke reduces both,” Rabinowitz said. .. “This study found that diet significantly reduced tumor glucose levels and dramatically reduced insulin levels compared to healthy tissue.”

By depriving the body of sugar, the ketogenic diet breaks down fat into the body, producing molecules called ketone bodies that can burn cells to generate energy. The most important of these is 3-hydroxybutyric acid.

“One of the things we noticed is that 3-hydroxybutyric acid acts like a supercharged fuel that emits electrons to cells, and tumor cells are wired to take up this fuel well for other reasons. That’s it, “says Rabinowitz. “Fortunately, too much of this supercharged fuel can be toxic to cancer.”

This excess electron causes the production of reactive oxygen species (ROS), a highly unstable molecule that is also produced by chemotherapy. ROS kill cancer cells by damaging the cells’ DNA, membranes, and other components. Researchers hypothesize that this may increase the antitumor effect of chemotherapy.

“The most exciting thing here is the ability to adopt a chemotherapy regimen that is known to be active, which gives patients the best chances of being in the clinic right now, at least in mice, pairing with the patient. By assembling, the work of the patient is greatly improved. Ketogenic diet“I hope patients will see the same effect,” says Rabino Witz.

Will a Ketogenic Diet Help With Brain Tumors?

For more information:
Lifeng Yang et al, a combination of ketogenic diet and chemotherapy, disrupts pancreatic cancer metabolism and growth, Med (2022). DOI: 10.1016 / j.medj.2021.12.008

Quote: Preclinical studies show that the ketogenic diet may enhance the treatment of pancreatic cancer (February 11, 2022) https://medicalxpress.com/news/2022-02-preclinical-ketogenic Obtained February 11, 2022 from -diet-pancreatic-cancer.html

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Preclinical studies show that the ketogenic diet may enhance the treatment of pancreatic cancer

Source link Preclinical studies show that the ketogenic diet may enhance the treatment of pancreatic cancer

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Fire Under Control Near Fountain Creek Park

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Update 11:12 a.m.

Firefighters put out a wildland fire early Thursday in the Fountain area, officials said.

The blaze was reported about 3:45 a.m. on the east side of Fountain Creek and south of Duckwood Park, Fountain police said in news release. Crews from fire departments in Security, Stratmoor Hills, Fort Carson and Hanover responded to heavy smoke and flames.

The fire was about a mile west of Colorado 85.

“The mild weather conditions this morning made it easier for fire crews to get this fire under control quickly,” police said.

The fire burned less than an acre before it was fully contained, officials said. As of Thursday morning, officials said the area is being monitored and might take several hours before the scene is cleared.

The cause of the fire is under investigation but officials said a lightning strike Wednesday afternoon might have ignited it.

Update 11 a.m.: The fire is 100% contained and burned less than one acre. No structures were threatened and no reported injuries.

The cause of the fire is still under investigation, however, officials think it possibly started from a lightning strike due to later afternoon storms on Wednesday.

Fountain fire department battled a wildland fire near Fountain Creek Regional Park Thursday morning, Fountain police said.

The fire ignited around 3:30 a.m. between Hwy 85 and Comanche Village Drive and crews managed to get the fire under control, police said.

Containment was 50% as of 7 a.m. but police did not give any estimates of the fire’s size.

The cause of the fire is under investigation, police said.


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Original Post: gazette.com

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911 Lines Down in Fremont and Custer Counties, Officials Say

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Fremont and Custer counties have been without 911 services since Wednesday afternoon, officials said.

According to the Fremont County Emergency Management, the lines have been down since 5:15 p.m. Wednesday. The public is asked to not call 911 “to test or check your phone.”

Calls will be be routed to the Pueblo County Sheriff’s Office, officials said. From there, they will be transferred back to Fremont County dispatchers.

This is a developing story. Check with gazette.com for updates.


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Original Source: gazette.com

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Alaska Rep. Don Young to Lie in State at US Capitol

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Rep. Don Young, the longest-serving Republican in U.S. House history, will lie in state in the U.S. Capitol on March 29.Read More

Original Article: seattletimes.com

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